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Dysregulated SLC25A45 proteostasis associates with altered MeAA levels in humans Consistent with our metabolic and biochemical characterization of SLC25A45, analysis of a recent genome-wide association study (GWAS) revealed a strong association between the SLC25A45 missense variant R285C (rs34400381) and levels of trimethyllysine ( p value: 1.9 × 10 −80 ), deoxycarnitine ( p value: 1.3 × 10 −15 ), and dimethylarginine ( p value: 1.4 × 10 −8 ) in the plasma metabolome of 6,136 Finnish male participants (METSIM) 49 (Figure 2A)